Preparing Kaempferol Nanosuspension (KNS) using High Pressure Homogenization (HPH) technique

Background During the last decades, researchers have provided a plethora of therapeutic uses of kaempferol, including anticancer, anti-inflammatory, neuroprotective, anti-oxidative and anti-oestrogenic activities, making kaempferol a valuable compound [1]. However, being a poor water-soluble compound, kaempferol often has insufficient solubility and bioavailability [2].To find a solution for this limitation, this research project mainly focuses on formulating a kaempferol nanosuspension (KNS) using High Pressure Homogenisation (HPH), followed by performing physiological characterization. Kaempferol nanosuspensions are supposed to have a better bioavailability in animal models or even human subjects in future experiments, thereby reducing oral drug dosage required by consumers.